HORDB

ID: hor000631
Uniprot ID: Q9VC44
Protein name: Drostatin-1
Gene name: AstA
Organism: Drosophila melanogaster (Fruit fly)
Family: Allatostatin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: melanogaster subgroup, melanogaster group, Sophophora (subgenus), Drosophila (genus), Drosophilini (tribe), Drosophilinae (subfamily), Drosophilidae (family), Ephydroidea (superfamily), Acalyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0071855 neuropeptide receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0045968 negative regulation of juvenile hormone biosynthetic process
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: VERYAFGL
Length: 8(57-64)
Propeptide: MNSLHAHLLLLAVCCVGYIASSPVIGQDQRSGDSDADVLLAADEMADNGGDNIDKRVERYAFGLGRRAYMYTNGGPGMKRLPVYNFGLGKRSRPYSFGLGKRSDYDYDQDNEIDYRVPPANYLAAERAVRPGRQNKRTTRPQPFNFGLGRR
Signal peptide: MNSLHAHLLLLAVCCVGYIAS
Modification: T8 Leucine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000631_AF2.pdb

hor000631_ESM.pdb

Mass:	107913	Formula:	C45H67N11O12
Absent amino acids:	CDHIKMNPQSTW	Common amino acids:	AEFGLRVY
pI:	6.4	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	36.25	Boman Index:	-718
Half-Life:	100 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	97.5
Instability Index:	2892.5	Extinction Coefficient cystines:	1490
Absorbance 280nm:	212.86